Dick Briefer is famous among knowledgeable comic buffs (particularly here in Mippyville) as one of the best and most innovative cartoonists of the Golden Age. His fame rests almost entirely on his three interpretations of one character, Frankenstein.
But Briefer created other series as well and at least one also deserves a place in the history books. Keri Krane was (as far as I can tell) the first tough female private eye appearing in genuine noir stories. Briefer's style was light and there were humorous touches but these were not funny stories. As you can see here, Krane dealt with truly bad people and faced dangers that were decidedly non-cartoonish.